Abstract
Compounds that control rice blast, but not other crop diseases, were selected for testing as inhibitors of trihydroxynaphthalene reductase of the fungal melanin biosynthetic pathway. A potent inhibitor of the enzyme (2) (Ki = 25 nM) was identified. An X-ray structure of the enzyme-NADPH-2 complex was determined at 2.1 A resolution.
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Databases, Factual
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Fungal Proteins*
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Fungi / drug effects*
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Melanins / biosynthesis
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Molecular Conformation
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NADP / chemistry
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Oryza
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Oxidoreductases / antagonists & inhibitors*
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Oxidoreductases Acting on CH-CH Group Donors*
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Plant Diseases / microbiology*
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X-Ray Diffraction
Substances
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Antifungal Agents
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Enzyme Inhibitors
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Fungal Proteins
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Melanins
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NADP
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Oxidoreductases
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tetrahydroxynaphthalene reductase
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Oxidoreductases Acting on CH-CH Group Donors